NABL Accredited · Solid State Analysis Laboratory

XRD Analysis Laboratory India | X-Ray Diffraction Testing | NABL

XRD analysis (X-Ray Diffraction) services from an NABL-accredited pharmaceutical testing laboratory in India. Polymorphism screening, crystal structure, and amorphous content analysis.

X-Ray Diffraction (XRD) is the definitive analytical technique for determining the crystallographic structure and polymorphic identity of pharmaceutical substances. Auriga Research operates an NABL-accredited XRD analysis laboratory equipped with powder X-ray diffractometers capable of high-resolution phase identification, quantitative phase analysis, and crystallinity determination for APIs, excipients, and formulated products.

In pharmaceutical development, XRD testing serves as the primary tool for polymorphism screening — identifying all crystalline forms a drug substance can adopt. Each polymorph produces a unique diffraction fingerprint, enabling unambiguous form identification, batch-to-batch consistency verification, and detection of unintended polymorphic conversions during processing or storage. XRD data is essential for CTD Module 3 solid-state characterisation and patent filings involving crystalline form claims.

Our XRD capabilities extend to amorphous content quantification, preferred orientation analysis, crystallite size determination by Scherrer analysis, and variable-temperature XRD for studying phase transitions under thermal stress. Combined with DSC and TGA data, XRD provides the comprehensive solid-state characterisation package required by regulatory agencies worldwide.

XRD Testing Capabilities

  • Powder X-ray diffraction (PXRD) for phase identification and polymorphic form fingerprinting
  • Polymorphism screening and quantitative polymorph mixture analysis
  • Amorphous content quantification for solid dispersions and spray-dried materials
  • Crystallinity index determination for APIs and excipients
  • Rietveld refinement for quantitative phase analysis
  • Crystallite size determination by Scherrer analysis
  • Variable-temperature XRD for thermally-induced phase transitions
  • Database matching against ICDD and Cambridge Structural Database

Turnaround Time

Standard XRD Analysis: 5-7 business days
Rush XRD Analysis: 2-3 business days
Polymorph Screening Programme: 7-14 business days
Full Solid-State Package (XRD+DSC+TGA): 10-14 business days

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Frequently Asked Questions — XRD Testing

What is XRD analysis and what does it measure?
XRD (X-Ray Diffraction) analysis is a technique that determines the crystallographic structure, phase composition, and crystallinity of materials by directing X-rays at a sample and measuring the diffraction pattern. In pharmaceutical applications, XRD identifies polymorphic forms, distinguishes crystalline from amorphous content, confirms crystal structure identity, and quantifies mixtures of polymorphic phases. Each crystalline form produces a unique diffraction pattern that serves as a fingerprint for identification.
How does XRD testing support pharmaceutical polymorphism studies?
XRD is the definitive technique for polymorphic form identification because each polymorph has a unique crystal structure that produces a distinct diffraction pattern. XRD testing supports polymorph screening, form identification during process development, batch-to-batch consistency checks, patent support with crystallographic data, and regulatory submissions requiring solid-state characterisation in CTD Module 3. Combined with DSC and TGA, XRD provides complete polymorphic characterisation.
What is the turnaround time for XRD testing?
Standard XRD testing at Auriga Research is completed within 5-7 business days from sample receipt. Polymorph screening programmes with multiple samples require 7-14 business days. Rush XRD analysis is available within 2-3 business days for urgent characterisation needs.

Need XRD Analysis for Your Pharmaceutical Samples?

NABL-accredited X-Ray Diffraction analysis with 5-7 day turnaround. Polymorphism screening, crystal structure, and amorphous content reports.

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