DSC Analysis Laboratory India | Differential Scanning Calorimetry | NABL

DSC stands for Differential Scanning Calorimetry. It is one of the most widely used thermal analysis techniques in pharmaceutical development and quality control. DSC measures the heat flow difference between a sample and an inert reference as both are heated, cooled, or held at a constant temperature. Auriga Research operates an NABL-accredited DSC analysis laboratory equipped with high-sensitivity calorimeters capable of detecting thermal events with precision down to 0.1 mW.

Pharmaceutical applications of DSC analysis are extensive. The technique provides definitive data on polymorphic form identity through characteristic melting endotherms, enabling polymorph screening and batch-to-batch consistency checks. For purity determination, DSC applies the van't Hoff equation to melting point depression data, offering a rapid and material-efficient alternative to chromatographic methods. Glass transition temperature (Tg) measurements by DSC are critical for amorphous solid dispersions and spray-dried intermediates where stability depends on maintaining the amorphous state.

DSC analysis also supports drug-excipient compatibility screening, where binary mixtures are heated to detect new thermal events that indicate interaction. Combined with TGA and XRD data, DSC forms the core of solid-state characterisation packages required for CTD Module 3 regulatory submissions. Our laboratory provides ICH-compliant thermal analysis with detailed interpretation reports.