TGA Analysis Laboratory India | Thermogravimetric Analysis Services | NABL

TGA analysis — Thermogravimetric Analysis — is an essential thermal characterisation technique for pharmaceutical development and quality control, measuring the precise mass changes that occur in a substance as temperature increases under controlled atmospheric conditions. Auriga Research operates an NABL-accredited TGA analysis laboratory equipped with high-sensitivity microbalance instrumentation capable of detecting mass changes as small as 0.1 micrograms, providing pharmaceutical manufacturers, API producers, and formulation scientists with the thermal decomposition, moisture content, and compositional data they need for regulatory submissions and process optimisation.

The TGA full form — Thermogravimetric Analysis — describes a technique where a sample is heated at a controlled rate (typically 10 C/min) from ambient temperature up to 1000 C while a precision microbalance continuously records the sample mass. Weight loss events correspond to specific thermal processes: evaporation of moisture and residual solvents below 150 C, desolvation of crystalline solvates between 100-250 C, decomposition of organic material above 200 C, and oxidation or reduction events depending on the atmosphere used. Our TGA instruments operate under inert (nitrogen, argon) or oxidative (air, oxygen) atmospheres to characterise these events under different conditions.

Pharmaceutical applications of TGA analysis include determining residual solvent content in APIs per ICH Q3C, quantifying bound and unbound moisture in hygroscopic materials, establishing the thermal stability window for processing and formulation, characterising polymorphic forms that differ in solvation state, and evaluating the composition of multi-component systems such as coated tablets or polymer-drug composites. When combined with DSC analysis, TGA provides a complete thermal fingerprint that supports polymorph screening, stability assessment, and regulatory dossier compilation.